Question: Can ACT have more than one configuration? (Almost required for multiple game support)

Aside from the Import/Export XML settings features, ACT will load configuration files named after itself.

As in normally it loads %APPDATA%\Advanced Combat Tracker\Config\Advanced Combat Tracker.config.xml. 

If you were to rename ACT's executable to ACT.exe, it would instead load %APPDATA%\Advanced Combat Tracker\Config\ACT.config.xml as its configuration file.

If you do this, you should also make a matching Advanced Combat Tracker.exe.config as that file is required for DLL plugins to work correctly.

Resuting in:
ACT.exe
ACT.exe.config

As there are now two separate ACT executable files, they must also be updated separately. Recent versions of ACT should properly auto-update their own existence.